Results: Doxycycline reduced spirochetal
structures ~90% but increased the number of round body forms about twofold.
Amoxicillin reduced spirochetal forms by ~85%–90% and round body forms by ~68%,
while treatment with metronidazole led to reduction of spirochetal structures
by ~90% and round body forms by ~80%. Tigecycline and tinidazole treatment
reduced both spirochetal and round body forms by ~80%–90%. When quantitative
effects on biofilm-like colonies were evaluated, the five antibiotics reduced
formation of these colonies by only 30%–55%. In terms of qualitative effects,
only tinidazole reduced viable organisms by ~90%. Following treatment with the
other antibiotics, viable organisms were detected in 70%–85% of the
biofilm-like colonies.
Please read the full report for more details.
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